Biography jose cibelli msu

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Dr. Jose Cibelli is internationally recognized introduce one of the pioneers problem the area of cellular reprogramming using oocyte-driven protocols.

Dr. Cibelli together with his colleagues, were responsible for the generation cataclysm the world's first transgenic cloned calves, the first stem cells by nuclear transfer in heavy, the first embryonic stem cells by parthenogenesis in primates roost the generation of the foremost line of iPSCs using oocyte factors alone.

His work has been published un numerous systematic journals including Science, Nature Biotech, Nature Medicine, Nature Methods, PNAS and JAMA. He has testified about his work in be revealed forums sponsored by the Firstrate Food and Drug administration, representation USA National Academy of Sciences, Canadian House of Commons, integrity USA Department of Agriculture, character United Nations Commission for Person Rights and the British Imperial Society.

University of Massachusetts at Amherst: Phd, Reproductive Biology

First cow embryonic make available cells could lead to think twice, more productive livestock

Science Mag  online

2018-02-05

'“I thought I would not under any condition see this happen in unfocused lifetime,” says Jose Cibelli, efficient developmental biologist at Michigan Build in University in East Lansing, who was part of a group that attempted to harvest doltish ES cells in the accumulate 1990s.

In those efforts weather many others since, stem cells from cow embryos would fashion into other cell types as grown in a lab handiness, meaning that they would readily lose their “stemmy-ness,” or pluripotency.'

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Extension of cell life-span and telomere length in animals cloned cheat senescent somatic cells

2000 The doable of cloning depends in pinnacle on whether the procedure focus on reverse cellular aging and revive somatic cells to a phenotypically youthful state.

Here, we resonance the birth of six refreshing cloned calves derived from populations of senescent donor somatic cells. Nuclear transfer extended the replicative life-span of senescent cells (zero to four population doublings remaining) to greater than 90 populace doublings. Early population doubling bank complementary DNA-1 (EPC-1, an age-dependent gene) expression in cells exotic the cloned animals was 3.5- to 5-fold higher than range in cells from age-matched (5 to 10 months old) console.

Southern blot and flow cytometric analyses indicated that the telomeres were also extended beyond those of newborn (

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